SOCRA CCRP New Braindumps Questions, CCRP Valid Cram Materials
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100% Pass SOCRA - CCRP - Accurate Certified Clinical Research Professional (CCRP) New Braindumps Questions
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SOCRA CCRP Exam Syllabus Topics:
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SOCRA Certified Clinical Research Professional (CCRP) Sample Questions (Q95-Q100):
NEW QUESTION # 95
An investigator is working with a new sponsor to submit a cardiovascular trial to the IRB/IEC. In accordance with the ICH GCP Guidelines, which parties should sign the protocol to confirm agreement that the trial will be conducted as agreed?
- A. The investigator/institution and the sponsor
- B. The sponsor and the FDA
- C. The investigator/institution and the delegated site staff
- D. The sponsor and the IRB/IEC
Answer: A
Explanation:
Theprotocol signature pagedocuments agreement between the sponsor and the investigator/institution to conduct the trial in compliance with ICH GCP, the protocol, and regulatory standards.
* ICH E6(R2) 8.2.2 (Signed protocol and amendments):Requires "the sponsor and investigator
/institution to sign the protocol and amendments, confirming agreement."
* ICH E6(R2) 4.5.1:"The investigator should conduct the trial in compliance with the protocol agreed to by the sponsor and, if required, approved by the regulatory authority(ies) and by the IRB/IEC." The sponsor-investigator signatures ensure shared accountability for subject protection, data integrity, and adherence to trial methodology. Neither delegated staff (B) nor IRB/IEC (C) nor FDA (D) sign protocols.
These bodies approve or oversee, but do not formally enter into execution of the protocol.
Thus, the correct answer isA (The investigator/institution and the sponsor).
References:
ICH E6(R2), §8.2.2 (Signed protocol and amendments).
ICH E6(R2), §4.5.1 (Investigator compliance with protocol).
NEW QUESTION # 96
An unconscious patient experiencing life-threatening cardiac arrhythmias has been admitted to an emergency room. No FDA-approved treatment is available, and no legal representative is present. The clinical investigator determined that the use of an investigational antiarrhythmic drug is required. In accordance with the CFR, who must certify the investigator's determination?
- A. The sponsor's study monitor
- B. The sponsor's medical monitor
- C. An independent physician
- D. A sub-investigator
Answer: C
Explanation:
This scenario falls underemergency use of investigational drugs without informed consent.
* 21 CFR 50.23(a):Allows waiver of informed consent if subject faces a life-threatening condition, available treatments are unproven, and immediate use is required.
* 21 CFR 50.23(a)(3):Requires that "the determination... be reviewed and concurred with by a physician who is not otherwise participating in the clinical investigation." Thus, anindependent physician(not part of the trial team) must certify the necessity of emergency investigational use.
Sponsors and monitors (C, D) are not authorized by regulation to make such determinations. Sub-investigators (A) lack independence and would be conflicted.
Correct answer:B (Independent physician).
References:
21 CFR 50.23(a)(3).
NEW QUESTION # 97
Which of the following is one of the responsibilities of an investigator who is NOT a sponsor?
- A. Maintaining control of the investigational product
- B. Reporting serious adverse events to the applicable regulatory agency
- C. Ensuring proper monitoring of an investigation at all investigational sites
- D. Ensuring that all participating investigators are promptly informed of significant new adverse events
Answer: A
Explanation:
For non-sponsor investigators, responsibilities are limited tosite-level conduct and product accountability.
* ICH E6(R2) 4.6.1:"Responsibility for investigational product(s) accountability at the trial site rests with the investigator/institution."
* 21 CFR 312.61:Requires the investigator to administer investigational drugs only to subjects under their supervision and maintain control.
Other responsibilities listed belong tosponsors:
* A: Reporting SAEs to FDA is a sponsor duty (investigators report to sponsor, not directly to FDA).
* B: Monitoring at all sites is a sponsor responsibility.
* C: Disseminating safety updates is a sponsor's role.
Correct answer:D (Maintaining control of IP).
References:
ICH E6(R2), §4.6.1.
21 CFR 312.61.
NEW QUESTION # 98
A company's CEO wants to commercially promote a device under an IDE study. This plan:
- A. Requires IRB/IEC approval
- B. Would violate FDA regulations
- C. Requires a large advertising budget
- D. Requires IDE approval
Answer: B
Explanation:
* 21 CFR 812.7:Prohibits promotion of investigational devices or claiming safety/effectiveness until FDA approval is granted.
* Investigational devices may only be used in clinical trials, not marketed.
Thus, promotion during an IDE study is anFDA violation.
References:21 CFR 812.7.
NEW QUESTION # 99
An investigator received $60,000 equity interest three years after study completion. What is the financial reporting requirement?
- A. None
- B. Report to FDA
- C. Report to sponsor
- D. Report to OHRP
Answer: A
Explanation:
* 21 CFR 54.4(b):Requires disclosureduring the study and for 1 year after completion.
* After three years, no disclosure is required.
References:21 CFR 54.4(b).
NEW QUESTION # 100
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